منابع مشابه
Sigma-1 Receptor Chaperones at the ER- Mitochondrion Interface Regulate Ca2+ Signaling and Cell Survival
Communication between the endoplasmic reticulum (ER) and mitochondrion is important for bioenergetics and cellular survival. The ER supplies Ca(2+) directly to mitochondria via inositol 1,4,5-trisphosphate receptors (IP3Rs) at close contacts between the two organelles referred to as mitochondrion-associated ER membrane (MAM). We found here that the ER protein sigma-1 receptor (Sig-1R), which is...
متن کاملBiochemical Pharmacology of the Sigma-1 Receptor.
The sigma-1 receptor (S1R) is a 223 amino acid two transmembrane (TM) pass protein. It is a non-ATP-binding nonglycosylated ligand-regulated molecular chaperone of unknown three-dimensional structure. The S1R is resident to eukaryotic mitochondrial-associated endoplasmic reticulum and plasma membranes with broad functions that regulate cellular calcium homeostasis and reduce oxidative stress. S...
متن کاملFocus on molecules: the Sigma-1 receptor.
The Sigma-1 receptor (accession number NP 005857) has no known homology with other receptors and in fact most closely resembles a C-8,7 sterol isomerase found in fungi (Hayashi and Su, 2003). The gene encodes a protein consisting of 223 amino acids with two transmembrane spanning domains and a typical argenine-argenine (R–R) endoplasmic reticulum (ER) locating signal near the N terminal end. Th...
متن کاملThe calcium-sensitive Sigma-1 receptor prevents cannabinoids from provoking glutamate NMDA receptor hypofunction: implications in antinociception and psychotic diseases.
Through the cannabinoid receptor 1 (CB1), the endocannabinoid system plays a physiological role in maintaining the activity of glutamate N-methyl-D-aspartate (NMDA) receptor within harmless limits. The influence of cannabinoids must be proportional to the stimulus in order to prevent NMDAR overactivation or exaggerated hypofunction that may precipitate symptoms of psychosis. In this framework, ...
متن کاملThe sigma-1 receptor: roles in neuronal plasticity and disease.
Sigma-1 receptors (Sig-1Rs) have been implicated in many neurological and psychiatric conditions. Sig-1Rs are intracellular chaperones that reside specifically at the endoplasmic reticulum (ER)-mitochondrion interface, referred to as the mitochondrion-associated ER membrane (MAM). Here, Sig-1Rs regulate ER-mitochondrion Ca(2+) signaling. In this review, we discuss the current understanding of S...
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ژورنال
عنوان ژورنال: Central Nervous System Agents in Medicinal Chemistry
سال: 2009
ISSN: 1871-5249
DOI: 10.2174/1871524910909030184